A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4045 (2006.01) A61K 31/405 (2006.01) A61P 35/00 (2006.01) C07D 519/00 (2006.01) C07D 519/04 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2679435
The present invention relates to the use of particular macrocycles that are inhibitors of the proteasomic degradation of p27, in particular Argyrin and derivatives thereof, preferably Argyrin A, for the treatment of proliferative diseases, such as cancer, as well as the derivatization of said macrocycles.
La présente invention concerne l'utilisation de macrocycles particuliers qui sont des inhibiteurs de la dégradation protéasomique de p27, en particulier l'argyrine et ses dérivés, de préférence l'argyrine A, pour le traitement de maladies à évolution chronique, telles que le cancer. Elle concerne en outre la dérivatisation desdits macrocycles.
Frank Ronald
Hinkelmann Bettina
Malek Nisar
Nickeleit Irina
Sasse Florenz
Heenan Blaikie Llp
Helmholtz-Zentrum Fuer Infektionsforschung Gmbh
Medizinische Hochschule Hannover
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