Use of inhibitors of the ubiquitin proteasome pathway for...

Details Use of inhibitors of the ubiquitin proteasome pathway for... Use of inhibitors of the ubiquitin proteasome pathway for...

A - Human Necessities

61

K

A61K 38/06 (2006.01) A61P 9/04 (2006.01)

Patent

CA 2614959

The present invention describes novel uses for inhibitors of the ubiquitin proteasome degradative pathway. In particular it describes methods for improving cardiac function, increasing alpha myosin levels in the heart, and increasing SERCA levels in the heart. The invention also provides methods for treating cardiac hypertrophy through inhibiton of the ubiquitin proteasome.

L'invention concerne de nouvelles utilisations d'inhibiteurs de la voie de dégradation ubiquitine-protéasome. L'invention se rapporte, en particulier, à des procédés qui permettent d'améliorer la fonction cardiaque, d'augmenter les niveaux de myosine alpha dans le coeur, et d'augmenter les niveaux de la SERCA dans le coeur. L'invention porte également sur des procédés qui permettent de traiter l'hypertrophie cardiaque en inhibant l'ubiquitine-protéasome.

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