Use of inhibitors of vacuolar-type h atpases

Details Use of inhibitors of vacuolar-type h atpases Use of inhibitors of vacuolar-type h atpases

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 31/16 (2006.01) A61K 31/71 (1995.01)

Patent

CA 2142313

The activity of inhibitors of vacuolar type H + -ATPases in the inhibition of vacuolation induced by Helicobacter pylori is disclosed. Preferred agents are the macrolide antibiotics bafilomycins A1, A2, B1, B2, C1, C2 and D, especially bafilomycin A1. The use of such compounds in the treatment of diseases, including peptic ulceration, is claimed.

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