A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/665 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2636089
Inositol-tripyrophosphate is an allosteric effector of hemoglobin due to its ability to cross the plasma membrane of red blood cells and deliver oxygen to solid tumors, by lowering the oxygen affinity of the hemoglobin of red blood cells. The present invention is directed to the use of inositol- tripyrophosphate to reduce hemoglobin's affinity for oxygen in circulating red blood cells. The present invention is further directed to the use of inositol- tripyrophosphate to inhibit angiogenesis and enhance radiation sensitivity of hypoxic tumors. The present invention is further directed to the use of inositol-tripyrophosphate to enhance PO2 in hypoxic tumors.
L'inositol-tripyrophosphate est un effecteur allostérique de l'hémoglobine du fait de sa capacité à traverser la membrane plasmatique des globules rouges et à libérer l'oxygène au niveau des tumeurs solides, en diminuant l'affinité vis-à-vis de l'oxygène de l'hémoglobine des globules rouges. La présente invention concerne l'emploi d'inositol-tripyrophosphate dans la réduction de l'affinité de l'hémoglobine pour l'oxygène dans les globules rouges en circulation. La présente invention concerne également l'emploi d'inositol-tripyrophosphate dans l'inhibition de l'angiogenèse et dans l'amélioration de la sensibilité vis-à-vis des rayonnements des tumeurs hypoxiques. La présente invention concerne en outre l'emploi d'inositol-tripyrophosphate dans l'amplification de PO2 dans les tumeurs hypoxiques.
Fylaktakidou Konstantina C.
Greferath Ruth
Lehn Jean-Marie
Nicolau Claude
Finlayson & Singlehurst
Normoxys Inc.
Oxyplus Inc.
Universite de Strasbourg
Universite Louis Pasteur de Strasbourg
LandOfFree
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