Use of interleukin-1 conjugates in the treatment of diabetes

Details Use of interleukin-1 conjugates in the treatment of diabetes Use of interleukin-1 conjugates in the treatment of diabetes

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 39/12 (2006.01) A61P 3/10 (2006.01) C07K 14/545 (2006.01)

Patent

CA 2717108

The invention provides compositions, pharmaceutical compositions and vaccines for the treatment, amelioration and / or prophylaxis of diabetes, preferably of type II diabetes. The compositions, pharmaceutical compositions and vaccines of the invention comprise a core particle and an antigen, wherein said antigen comprises an interleukin-1 (IL-I) molecule. When administered to an animal, preferably to a human, said compositions, pharmaceutical compositions, and vaccines induce efficient immune responses, in particular antibody responses, wherein typically and preferably said antibody responses are directed against IL-I. Thus, the invention provides methods of treating, ameliorating or preventing diabetes, preferably type II diabetes, by way of active immunization against IL-I.

La présente invention concerne des compositions, des compositions pharmaceutiques, et des vaccins pour le traitement, l'amélioration et/ou la prophylaxie du diabète, de préférence du diabète de type II. Les compositions, les compositions pharmaceutiques, et les vaccins de l'invention comprennent un noyau et un antigène, ledit antigène comprenant une molécule d'interleukine-1 (IL-1). Lorsque lesdites compositions, lesdites compositions pharmaceutiques, et lesdits vaccins sont administrés à un animal, de préférence à un être humain, ils induisent des réponses immunitaires efficaces, des réponses d'anticorps en particulier, ces réponses d'anticorps étant dirigées, d'une façon générale et préférentielle contre la molécule IL-1. Dans ces conditions, la présente invention propose des procédés de traitement, d'amélioration ou de prévention du diabète, et du diabète de type II de préférence, par le biais d'une immunisation active contre la molécule IL-1.

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