C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/08 (2006.01) A61K 38/20 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) C12N 5/06 (2006.01) A61K 35/12 (2006.01)
Patent
CA 2253803
Interleukin-10 for producing a population of cells which are capable of inhibiting or suppressing reactions to alloantigens, for example in graft- versus-host disease or tissue rejection, is described. Interleukin-10 for reducing responses in mixed lymphocyte response (MLR) is also described. Exogenous or induced endogenous IL-10 may be used for the inhibition or suppression of the reactions to alloantigens.
Utilisation d'interleukine-10 pour produire une population de lymphocytes capables d'inhiber ou de supprimer les réactions aux alloantigènes, par exemple dans la maladie greffe contre hôte ou le rejet de tissus. L'invention concerne également l'utilisation d'interleukine-10 pour diminuer les réactions dans la réaction lymphocytaire mixte (RLM). Pour inhiber ou supprimer les réactions aux alloantigènes on peut utiliser de l'IL-10 exogène ou de l'IL-10 endogène induite.
Bacchetta Rosa
de Vries Jan E.
de Waal Malefyt Rene
Groux Herve M.
Roncarolo Maria-Grazia
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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