Use of interleukin-4 antagonists and compositions thereof

Details Use of interleukin-4 antagonists and compositions thereof Use of interleukin-4 antagonists and compositions thereof

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61P 19/02 (2006.01) A61P 31/04 (2006.01)

Patent

CA 2409267

Methods for treating medical conditions induced by interleukin-4 involve administering an IL-4 antagonist to a patient afflicted with such a condition. Suitable IL-4 antagonists include, but are not limited to, IL-4 receptors (such as a soluble human IL-4 receptor), antibodies that bind IL-4, antibodies that bind IL-4R, IL-4 muteins that bind to IL-4R but do not induce a biological response, molecules that inhibit IL-4-induced signal transduction, and other compounds that inhibit a biological effect that results from the binding of IL-4 to a cell surface IL-4R. Particular antibodies provided herein include human monoclonal antibodies generated by procedures involving immunization of transgenic mice. Such human antibodies may be raised against human IL-4 receptor. Certain of the antibodies inhibit both IL-4-induced and IL-13-induced biological activities.

L'invention concerne des procédés relatifs au traitement d'affections induites par l'IL-4, qui consistent à administrer aux patients des antagonistes vis-à-vis de l'IL-4. On peut citer comme antagonistes appropriés, entre autres, les récepteurs de l'IL-4 (du type IL-4R soluble humain), les anticorps qui se lient à l'IL-4, les anticorps qui se lient à l'IL-4R, les mutéines de l'IL-4 qui se lient à l'IL-4R mais sans induire de réponse biologique, les molécules qui inhibent la transduction des signaux correspondant à l'IL-4, et d'autres composés inhibant un effet biologique qui résulte de la liaison entre l'IL-4 et un IL-4R de surface cellulaire. Parmi les anticorps décrits figurent les anticorps monoclonaux humains résultant de procédures qui consistent à immuniser des souris transgéniques. On peut mobiliser ce type d'anticorps contre l'IL-4R. Certains des anticorps considérés inhibent à la fois les activités biologiques induites par l'IL-4 et par l'IL-3.

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