Use of intermediate-conductance potassium channels and...

A - Human Necessities – 61 – K

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A61K 31/423 (2006.01) A61K 31/4184 (2006.01) A61K 31/428 (2006.01) A61K 31/4422 (2006.01) A61K 38/17 (2006.01) A61P 17/06 (2006.01) A61P 43/00 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2433041

The invention relates to the use of intermediate-conductance, calcium- activated potassium channels and/or the nucleic acids coding for the same, from humans or mice, for the diagnosis, prevention and/or treatment of illnesses associated with disturbed keratinocyte activity. The invention also relates to the use of the same for identifying pharmacologically active substances. The invention further relates to the use of modulators of intermediate-conductance, calcium-activated potassium channels for the diagnosis, prevention and/or treatment of illnesses associated with disturbed keratinocyte activity.

L'invention concerne l'utilisation de canaux potassiques activés par le calcium de conductance intermédiaire ou d'acides nucléiques codant pour eux provenant de l'homme ou de la souris pour le diagnostic, la prévention ou le traitement d'affections liées à une activité kératinocytaire perturbée, ainsi que leur utilisation pour l'identification de principes actifs pharmacologiques. L'invention concerne également l'utilisation de modulateurs de canaux potassiques activés par le calcium de conductance intermédiaire pour le diagnostic, la prévention ou le traitement d'affections liées à une activité kératinocytaire perturbée.

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