Use of ionic cloud point modifiers to prevent particle...

A - Human Necessities – 61 – K

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A61K 9/51 (2006.01) A61K 9/14 (2006.01) A61K 47/48 (2006.01) A61K 49/04 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2102551

- 0 - ABSTRACT This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and an anionic or cationic surfactant as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred surface modifier is tyloxapol. Preferred anionic surfactants are dioctylsulfonesuccinate, sodium dodecyl sulfate and sodium oleate. Preferred cationic surfactants are dodecyltrimethylammonium bromide and cetrimide tetradecyl ammonium bromide. This invention further discloses a method of making nanoparticles having a surface modifier adsorbed on the surface and an anionic or cationic surfactant as a cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.

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