Use of isoquinoline derivatives for treating cancer and map...

Details Use of isoquinoline derivatives for treating cancer and map... Use of isoquinoline derivatives for treating cancer and map...

A - Human Necessities

61

K

A61K 31/4725 (2006.01) A61K 31/472 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2518530

This invention relates to the treatment of a disease that is characterized by an aberrant MAP kinase signaling pathway by administering a compound of the formula (I) wherein the variable substituents are defined herein, to a patient in need of such treatment. The inventive method is especially useful for the treatment of cancers that have a mutated RAF kinase, especially melanoma.

Cette invention a trait au traitement d'un état pathologique se caractérisant par une voie de signalisation aberrante de la kinase MAP, lequel traitement consiste à administrer à un patient un composé correspondant à la formule (I), formule dans laquelle les substituants variables sont définis dans le descriptif. La méthode selon l'invention se révèle des plus utile pour traiter des cancers liés à une kinase Raf ayant muté, les mélanomes notamment.

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