Use of isotropic, porous-wall polymeric membrane,...

Details Use of isotropic, porous-wall polymeric membrane,... Use of isotropic, porous-wall polymeric membrane,...

C - Chemistry, Metallurgy

12

P

195/145, 195/47

C12P 21/00 (2006.01) C12M 3/00 (2006.01) C12N 9/00 (2006.01)

Patent

CA 1186256

ABSTRACT OF THE DISCLOSURE Hollow fiber reactors for growing cells. Isotropic hollow fibers are supported in a housing inoculated with cells. Nutrient medium passing through the lumen undergoes a pressure drop resulting in radial convective flow: the nutrient medium flows outwardly from the lumen into the surrounding area adjacent the entry port and fluid sur- rounding the hollow fiber flows into the lumen adjacent the exit port. With the efficient distribution of nutrients and removal of product, high cell densities are achieved pro- viding for high product yields per unit reactor volume.

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