C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/47 (2006.01) A61K 31/14 (2006.01) A61K 31/205 (2006.01) A61P 27/02 (2006.01)
Patent
CA 2434911
The present invention relates to the technical field of stabilizing proteins, in particular to the therapeutic aspects of protein stabilization. L-carnitine is a useful agent for stabilizing proteins, and in a particularly favourable aspect in proteins used in the medical field. In a preferred aspect, L- carnitine is used for protecting chaperone activity, and in the medical field for preserving the activity of altered chaperone proteins. In connection with this invention L-carnitine is used for the preparation of a medicament for the treatment of diseases due to altered chaperone proteins, such as eye diseases, in particular cataract.
La présente invention concerne le domaine technique de la stabilisation de protéines, notamment les aspects thérapeutiques de la stabilisation protéique. La L-carnitine est un agent d'utilité en ce qui concerne la stabilisation de protéines, particulièrement en ce qui concerne les protéines utilisées dans le domaine médical. Dans un aspect préféré de l'invention, la L-carnitine est utilisée pour préserver l'activité de la chaperone, et dans le domaine médical pour préserver l'activité de protéines chaperone modifiées. Selon l'invention, la L-carnitine est utilisée pour la préparation d'un médicament servant à traiter des troubles liés aux protéines chaperone modifiées, telles que des troubles oculaires, notamment la cataracte.
Calvani Menotti
Fetherstonhaugh & Co.
Sigma-Tau Industrie Farmaceutiche Riunite S.p.a
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