Use of lanthanide-based nanoparticles as radiosensitizing...

Details Use of lanthanide-based nanoparticles as radiosensitizing... Use of lanthanide-based nanoparticles as radiosensitizing...

A - Human Necessities

61

K

A61K 51/12 (2006.01) A61K 9/51 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2702919

The invention relates to the use of nanoparticles having dimensions between 1 and 50 nm, at least one part of which is constituted of at least one oxide and/or one oxyhydroxide of at least lanthanide, said nanoparticles being: - either constituted of at least one oxide and/or one oxyhydroxide of at least one lanthanide, - or in the form of nanoparticles comprising an oxyhydroxide core of at least one lanthanide, and a coating constituted of a polysiloxane, optionally with organic molecules grafted to the surface or included within it, as a radiosensitizing agent in the manufacture of an injectable composition intended for improving the effectiveness of the treatment of a tumour by X-ray or gamma irradiation. It also relates to nanoparticles that are particularly suitable for the above use, constituted of a core constituted of at least one oxide and/or one oxyhydroxide of at least one lanthanide and of a polysiloxane coating comprising 1 to 5 silicons per lanthanide and of which at least 10% of the silicon atoms are linked to hydrophilic organic molecules having molar masses of less than 450 g/mol.

L'invention concerne l'utilisation de nanoparticules de dimensions comprises entre 1 et 50 nm, dont une partie au moins est constituée d'au moins un oxyde et/ou un oxohydroxyde d'au moins un lanthanide, lesdites nanoparticules étant : soit constituées d'au moins un oxyde et/ou un oxohydroxyde d'au moins un lanthanide, soit sous forme de nanoparticules comprenant un coeur oxohydroxyde d'au moins un lanthanide, et un enrobage constitué d'un polysiloxane, avec éventuellement des molécules organiques greffées en surface ou comprises en son sein, en tant qu'agent radio-sensibilisant dans la fabrication d'une composition injectable destinée à améliorer l'efficacité du traitement d'une tumeur par irradiations X ou gamma. Elle concerne également des nanoparticules particulièrement adaptées pour l'utilisation ci-dessus, constituées d'un coeur constitué d'au moins un oxyde et/ou un oxohydroxyde d'au moins un lanthanide et d'un enrobage en polysiloxane comprenant 1 à 5 silicium par lanthanide et dont au moins 10% des atomes de silicium sont liés à des molécules organiques hydrophiles de masses molaires inférieures à 450 g/mol.

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