Use of lck inhibitor for treatment of immunologic diseases

Details Use of lck inhibitor for treatment of immunologic diseases Use of lck inhibitor for treatment of immunologic diseases

A - Human Necessities

61

K

A61K 31/404 (2006.01) A61K 31/454 (2006.01) A61K 31/517 (2006.01) A61K 45/06 (2006.01) A61P 5/48 (2006.01) A61P 11/06 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2495350

The invention relates to a method of treating immunologc diseases or pathological conditions involving an immunologc component using Lck inhibitors already known as kinase inhibitors for therapy in oncology, optionally in combination with one or more other drugs selected from NSAIDs, steroids, DMARDs, immunsuppressive, biologic response modifiers and antinfectives, pharmaceutical compositions comprising said LcK inhibitoir together with said other drugs, and the use of LcK inhibitors for the manufacture of a pharmaceutical composition for the treatment of immunologic diseases or pathological conditions involving an immunologic component.

La présente invention concerne un procédé permettant de traiter des affections immunologiques ou des états pathologiques faisant intervenir une composante immunologique. On utilise à cet effet des inhibiteurs LcK déjà connus comme inhibiteurs des kinases pour les thérapies du domaine de l'oncologie. On peut y associer éventuellement un ou plusieurs des agents que sont les anti-inflammatoires non stéroïdiens, les stéroïdes, les antirhumatismaux modificateurs de la maladie, les immunosuppresseurs, les modificateurs de réponse biologiques, et les anti-infectieux. L'invention concerne aussi des compositions pharmaceutiques comprenant cet inhibiteur LcK associé aux autres médicaments mentionnés. L'invention concerne enfin l'utilisation de ces inhibiteurs LcK pour la fabrication d'une composition pharmaceutique destinée au traitement d'affections immunologiques ou des états pathologiques faisant intervenir une composante immunologique.

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