A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/454 (2006.01) A61K 39/395 (2006.01) A61P 7/02 (2006.01) A61P 7/06 (2006.01) A61P 37/02 (2006.01)
Patent
CA 2712724
Provided herein are methods of treating, preventing or managing disorders associated with low CD59 levels. The methods encompass the administration of an immunomodulatory compound provided herein, such as 3-(4-amino-l-oxo-l,3-dihydro-isoindol -2-yl)-piperidine-2,6-dione or 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4- aminoisoindoline. Further described are methods of treatment using the immunomodulatory compounds in combination with other therapeutic agents or therapies. Pharmaceutical compositions and single unit dosage forms suitable for use in the methods provided herein are also disclosed.
L'invention concerne des procédés de traitement, de prévention ou de gestion de troubles associés à de faibles taux de CD59. Les procédés englobent l'administration d'un composé immunomodulateur proposé ici, tel que la 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-pipéridine-2,6-dione ou la 1,3-dioxo-2-(2,6-dioxopipéridin-3-yl)-4-aminoisoindoline. Sont en outre décrits des procédés de traitement faisant intervenir les composés immunomodulateurs en combinaison avec d'autres agents thérapeutiques ou thérapies. Des compositions pharmaceutiques et des formes posologiques unitaires simples convenant à une utilisation dans les procédés proposés ici sont également décrites.
Brady Helen A.
Chan Kyle
Celgene Corporation
Smart & Biggar
LandOfFree
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