A - Human Necessities – 01 – N
Patent
A - Human Necessities
01
N
A01N 63/00 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) C07H 21/04 (2006.01) C07K 1/00 (2006.01) C12N 5/06 (2006.01) C12N 5/10 (2006.01) C12N 15/00 (2006.01) C12N 15/12 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2286819
The present invention provides methods for inducing immunity in a subject by using dendritic cells transduced with a lentivirus vector constructed to deliver an antigenic epitope. The methods of the invention are particularly suited to inducing immunity to human immunodeficiency virus (HIV) and other viral diseases, as well as to inducing immunity to tumor antigens.
La présente invention se rapporte à des procédés permettant d'induire une réponse immunitaire chez un sujet, qui consistent à utiliser des cellules dendritiques transduites par un vecteur de lentivirus conçu pour administrer un épitope antigénique. Les procédés de l'invention permettent notamment d'induire une réponse immunitaire dirigée contre le virus de l'immunodéficience humaine (VIH) et autres virus associés à des maladies virales, et d'induire une réponse immunitaire à des antigènes tumoraux.
Kan-Mitchell June
Li Xianqiang
Wong-Staal Flossie
Mbm & Co.
The Regents Of The University Of California
LandOfFree
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