G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) A61K 38/16 (2006.01) A61K 38/19 (2006.01) A61K 38/22 (2006.01) A61K 38/55 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2464277
Leptin, leptin analogs, and leptin derivatives are used to treat patients with lipodystrophy. Leptin is effective against lipodystrophy conditions for both genetic and acquired forms of the disease. A therapeutically effective amount of leptin can be administered in a variety of ways, including in a vector comprising nucleic acid sequences encoding leptin. Methods of the present invention contemplate administration of leptin, leptin analogs, and leptin derivatives to patients having approximately 4 ng/ml or less before treatment.
La présente invention concerne l'utilisation de leptine, d'analogues de leptine et de dérivés de leptine pour traiter des patients atteints de lipoatrophie. La leptine est efficace contre des pathologies de lipoatrophie, à la fois pour les formes génétiques et pour les formes acquises de la maladie. Une quantité de leptine efficace d'un point de vue thérapeutique peut être administrée de diverses façons, notamment par voie sous-cutanée et en mettant en oeuvre des méthodes de thérapie génique. Les procédés selon cette invention envisagent l'administration de leptine, d'analogues de leptine et de dérivés de leptine à des patients qui présentent un taux de leptine approximativement inférieur ou égal à 4 ng/ml avant le traitement.
Depaoli Alex M.
Garg Abhimanyu
Oral Elif Arioglu
Taylor Simeon I.
Amgen Inc.
Board Of Regents The University Of Texas System
Department Of Health And Human Services The Government Of The United States Of America As Represented By
Smart & Biggar
LandOfFree
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