Use of lipid conjugates in the treatment of diseases or...

C - Chemistry – Metallurgy – 09 – H

Patent

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Details

C09H 7/00 (2006.01) A61K 47/48 (2006.01) A61L 2/18 (2006.01) A61P 27/02 (2006.01) C08B 11/12 (2006.01) C08B 31/12 (2006.01) C08B 37/04 (2006.01) C08H 1/06 (2006.01) C09H 5/00 (2006.01)

Patent

CA 2705785

In one embodiment, the invention provides a method of treating, reducing the incidence, reducing the severity or pathogenesis of an eye disease or disorder in a subject, including, inter alia, retinal detachment, macular degeneration, glaucoma or retinopathy, comprising the step of administering an effective amount of a lipid or phospholipid moiety bound optionally via a spacer to a physiologically acceptable monomer, dimer, oligomer, or polymer via an ester or amide bond, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof. This invention also provides a contact lens solution comprising a lipid or phos-pholipid moiety bound optionally via a spacer to a physiologically acceptable monomer, dimer, oligomer, or polymer via an ester or amide bond, and/or a pharmaceutically acceptable salt or a pharmaceutical product thereof.

Un mode de réalisation de l'invention concerne une méthode de traitement, de réduction de l'incidence ou de réduction de la sévérité de la pathogénèse d'une maladie ou d'un trouble oculaire chez un sujet, comprenant notamment, le décollement de la rétine, la dégénérescence maculaire, le glaucome ou la rétinopathie. Cette méthode consiste à administrer au patient une dose efficace d'un fragment lipidique ou phospholipidique éventuellement lié par un espaceur à un monomère, dimère, oligomère, ou polymère physiologiquement acceptable via une liaison ester ou amide, et/ou un sel de qualité pharmaceutique ou un produit pharmaceutique associé. De plus, l'invention décrit une solution pour verres de contact qui contient un fragment lipidique ou phospholipidique éventuellement lié par un espaceur à un monomère, dimère, oligomère ou polymère physiologiquement actif via une liaison ester ou amide, et/ou un sel de qualité pharmaceutique ou un produit pharmaceutique associé.

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