Use of lipid containing particles comprising quillaja...

A - Human Necessities – 61 – K

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Details

A61K 31/704 (2006.01) A61K 39/39 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2669209

The present invention relates to the use of lipid containing particles, such as liposomes, iscom and/or iscom matrix and posintros, comprising at least one lipid and at least one saponin for the preparation of a pharmaceutical for the treatment of cancer. The saponins are preferably from Quillaja Saponaria Molin. Further, the particles are also delivery systems for one or several compounds for cancer treatment with complementary mechanisms. More, the invention discloses kit of parts comprising at least two parts, wherein one part comprising at least one saponin fraction which is hydrophobic having a killing effect on cancer cell; and the other part comprising at least one saponin fraction which is comparatively hydrophilic, stimulating and modulating the immune response.

La présente invention concerne l'utilisation de particules contenant des lipides, telles que des liposomes, un complexe immunostimulant et/ou une matrice de complexe immunostimulant et des posintros, dans la préparation d'un produit pharmaceutique destiné au traitement du cancer. Lesdites particules comprennent au moins un lipide et au moins une saponine. Les saponines proviennent de préférence du Quillaja Saponaria Molina. En outre, les particules constituent également des systèmes de fourniture d'un ou de plusieurs composés destinés au traitement du cancer avec des mécanismes complémentaires. Par ailleurs, l'invention concerne un kit de parties contenant au moins deux parties. L'une desdites parties comprend au moins une fraction de saponine qui est hydrophobe, et exerce un effet destructeur sur les cellules cancéreuses. L'autre partie comprend au moins une fraction de saponine qui est comparativement hydrophile, et peut stimuler et moduler la réponse immune.

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