A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/03 (2006.01) A61K 38/10 (2006.01) A61P 11/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2424285
The invention relates to the use of a lipopeptide or lipoprotein for preventing lung inflammation, for increasing the amount of lymphatic tissue in the bronchial mucosa and for treating lung infections and lung tumours. Said lipopeptide or lipoprotein has the general structure (I) wherein R1 and R2 can be the same or different and represent C7-25 alkyl, C7-25 alkenyl or C7-25 alkinyl, X represents S, O or CH2, W represents CO or S(O)n (n = 1 or 2) and Y represents a physiologically acceptable amino acid sequence consisting of between 1 and 13 amino acid radicals, and the asymmetric carbon atom marked with * has the absolute S configuration when X = S (sulphur).
L'invention concerne l'utilisation, pour prévenir l'apparition d'inflammations pulmonaires, pour faire proliférer le tissu lymphatique dans la muqueuse bronchique et pour traiter des infections et des tumeurs pulmonaires, d'un lipopeptide ou d'une lipoprotéine ayant la structure générale suivante : (I) dans laquelle R¿1? et R¿2? qui peuvent être identiques ou différents désignent alkyle C¿7-25?, alkényle C¿7-25? ou alkinyle C¿7-25?, X désigne S, O ou CH¿2?, W désigne CO ou S(O)n (n = 1 ou 2) et Y désigne une séquence d'aminoacide physiologiquement compatible comprenant entre 1 et 13 restes d'aminoacide et l'atome de carbone asymétrique marqué par * adopte la configuration S absolue, lorsque X = S (soufre).
Luhrmann Anke
Muhlradt Peter
Pabst Reinhard
Tschernig Thomas
Gesellschaft Fuer Biotechnologische Forschung Mbh (gbf)
Helmholtz-Zentrum Fuer Infektionsforschung Gmbh
Macrae & Co.
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