A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/66 (2006.01)
Patent
CA 2396393
This invention provides methods of inhibiting calcification of a soft tissue (e.g. an artery, a heart valve, an atherosclerotic plaque, a cancer, a kidney, a prostate, skin, muscle, cartilage, viscera, and heart muscle) in a mammal. These methods involve inhibiting osteoclastic bone resorption in said mammal (e.g., a mammal diagnosed as having or at risk for a pathology characterized by calcification of a soft tissue). The inhibition is preferably by administration of a bisphosphonate to the mammal in a concentration sufficient to inhibit bone resorption without inhibiting bone mineralization. The methods of this invention can also be used to mitigate a symptom of atherosclerosis in a mammal. Such methods involve inhibiting osteoclastic bone resorption in the mammal. In preferred embodiment, the inhibiting is by administration of a bisphophonate to the mammal in a concentration sufficient to inhibit bone resorption without inhibiting bone mineralization.
L'invention concerne des procédés relatifs à l'inhibition de la calcification de tissu mou (par exemple, artère, valvule du coeur, plaque d'athérosclérose, cancer, rein, prostate, peau, muscle, cartilage, viscères, et muscle cardiaque) chez un mammifère. Ces procédés consistent à inhiber la résorption osseuse ostéoclastique chez un mammifère (par exemple chez lequel on a diagnostiqué une pathologie caractérisée par une calcification de tissu mou ou qui présente ce risque de calcification). De préférence, on administre un biphosphonate selon une concentration suffisante pour inhiber la résorption sans inhiber la minéralisation osseuse. Les procédés considérés peuvent encore être utilisés pour atténuer un symptôme d'athérosclérose chez un mammifère. Ils consistent à inhiber la résorption osseuse ostéoclastique susmentionnée. En mode de réalisation préféré, l'inhibition repose sur l'administration d'un biphosphonate selon une concentration suffisante pour inhiber la résorption sans inhiber la minéralisation osseuse.
Smart & Biggar
The Regents Of The University Of California
LandOfFree
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