A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7125 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) A61P 37/06 (2006.01)
Patent
CA 2591586
This invention is related to the use of at least one oligonucleotide with a length of from about 8 to about 30 nucleotide building blocks for manufacturing a pharmaceutical preparation for the prophylaxis and/or the treatment of diseases, that are modulated by TGF-beta2, TGF-beta1, TGF-beta3, VEGF, interleukin-10, c-jun, c-fos, and/or prostaglandin E2 in a mammal, in particular for the treatment of cancer, metastases, disease of the nervous system or immunosuppression, wherein said oligonucleotide hybridizes with a messenger RNA of a TGF-beta2, TGF-betal, TGF-beta3, VEGF, interleukin- 10, c- jun, c-fos and/or prostaglandin E2 gene and wherein said preparation comprises said oligonucleotide in a concentration of about 1 microM to about 25 microM.
L'invention concerne l'utilisation d'au moins un oligonucléotide d'une longueur d'environ 8 à environ 30 éléments constitutifs nucléotidiques dans la fabrication d'une préparation pharmaceutique destinée à la prévention et/ou au traitement de maladies induites par TGF-bêta2, TGF-bêta1, TGF-bêta3, VEGF, interleukine-10, c-jun, c-fos et/ou prostaglandine E2 chez un mammifère, cet oligonucléotide s'hybridant avec un ARN messager d'un gène de TGF-bêta2, TGF-bêta1, TGF-bêta3, VEGF, interleukine-10, c-jun, c-fos et/ou prostaglandine E2, la préparation selon l'invention contenant cet oligonucléotide dans une concentration comprise entre environ 1 microM et environ 25 microM.
Schlingensiepen Karl-Hermann
Schlingensiepen Reimar
Antisense Pharma Gmbh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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