Use of low temperature and/or low ph in cell culture

Details Use of low temperature and/or low ph in cell culture Use of low temperature and/or low ph in cell culture

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2684727

The present invention provides a novel method of reducing protein misfolding and aggregation in the cell culture by growing the cell culture at a reduced temperature and/or reduced pH. As a result, the quality of the protein produced in the cell culture is greatly improved. Thus, the present invention facilitates improvements in the efficacy of therapeutic proteins produced in cell culture.

La présente invention concerne un nouveau procédé destiné à réduire le mauvais repliement et l'agrégation des protéines dans une culture cellulaire, en cultivant la culture cellulaire dans des conditions de température réduite et/ou de pH réduit. Il s'ensuit que la qualité de la protéine produite par culture cellulaire est considérablement améliorée. Par conséquent, la présente invention permet d'améliorer l'efficacité des protéines thérapeutique produites par culture cellulaire.

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