Use of lp82 to treat hematopoietic disorders

A - Human Necessities – 61 – K

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Details

A61K 38/48 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) A61P 7/06 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2433933

The present invention relates to a method of using a mammalian gene sequence and polypeptides encoded thereby to treat mammalian hematopoietic disorders. More specifically the present invention relates to methods of using compositions comprising at least one LP82 agonist, LP82 antagonist, LP82 polynucleotide, LP82 polypeptide, and/or LP82 antibody for the prevention and/or treatment of mammalian hematopoietic disorders, including, but not limited to, anemia, leukemia, and hematopoietic conditions caused by bone marrow transplantation or chemo-/radiation therapy.

L'invention concerne une méthode d'utilisation d'une séquence génétique mammifère et des polypeptides codées par celle-ci pour traiter les troubles hématopoïétiques chez les mammifères. Plus précisément, l'invention concerne des méthodes d'utilisation de compositions contenant au moins un agoniste de LP82, un antagoniste de LP82, un polynucléotide de LP82, un polypeptide de LP82, et/ou un anticorps de LP82 pour prévenir et/ou traiter des troubles hématopoïétiques chez les mammifères, notamment l'anémie, la leucémie, et les états hématopoïétiques induits par une greffe de moelle osseuse ou par la chimiothérapie/radiothérapie.

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