Use of lymphocytes transformed with...

Details Use of lymphocytes transformed with... Use of lymphocytes transformed with...

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 38/00 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2532630

Methods for treating disease and health conditions associated with the presence of TGF-.beta. including cancers, are provided comprising administering a therapeutically effective agent which acts as a TGF-.beta. antagonist and cathepsin B inhibitor or lymphocytes transformed with a gene for expressing such an agent for overcoming the lymphocyte evading effect of TGF-.beta..

L'invention concerne des méthodes permettant de traiter les maladies et les troubles de santé associés à la présence de TGF-.szlig., notamment les cancers. Ces méthodes consistent à administrer un agent présentant une efficacité thérapeutique, qui agit comme antagoniste du TGF-.szlig., et un inhibiteur de la cathepsine B, ou des lymphocytes transformés par l'introduction d'un gène permettant l'expression d'un tel agent, afin de contrer l'effet de protection contre les lymphocyte du TGF-.szlig..

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