Use of matrix metalloprotease inhibitors for the treatment...

Details Use of matrix metalloprotease inhibitors for the treatment... Use of matrix metalloprotease inhibitors for the treatment...

A - Human Necessities

61

K

A61K 31/00 (2006.01) A61K 31/4439 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2418146

The invention relates to the use of an active agent, particularly an inhibitor, in treating cancer by influencing, preferably inhibiting the expression of matrix-metalloproteases. The targets for this active agent can especially related to downstream regulators of the matrix-metalloprotease 9 (MMP-9) signal transduction pathway. According to the invention, especially inhibitors of p38beta and p38gamma as also of mitogen-activated kinase kinase 6 (MKK6) and mitogen-activated kinase kinase 3 (MKK3) can be applied.

L'invention concerne l'utilisation d'un principe actif, en particulier d'un inhibiteur, pour le traitement du cancer, ledit principe actif influant sur l'expression de métalloprotéases matricielles. Les cibles de ce principe actif peuvent concerner les régulateurs agissant en aval de la voie de transduction du signal de la métalloprotéase matricielle 9 (MMP-9). Selon l'invention, on peut notamment utiliser des inhibiteurs de p38 bêta et p38 gamma comme kinase kinase 6 activée par mitogène (MKK6) et kinase kinase 3 activée par mitogène (MKK3).

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