C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/50 (2006.01)
Patent
CA 2617961
The use of matrix metalloproteinases, mutated and not mutated, for the preparation of pharmaceutical compositions useful in the treatment of pathologies assiciated with an accumulation of matrix bio-polymers and/or an excess of TIMPs (Tissue Inhibitors MetalloProteinases) is described; mutated matrix metalloproteinases, in which at least an aminoacid residue in a definite position in the protein, has been mutated into a hydrophilic and/or charged aminoacidic residue, obtaining an increased stability toward autoproteolysis are also described.
La présente invention concerne l'utilisation de métalloprotéinases matricielles mutées et non mutées pour la préparation de compositions pharmaceutiques utiles dans le traitement de pathologies associées à une accumulation de biopolymères matriciels et/ou à un excès de TIMP (métalloprotéinases d'inhibiteurs tissulaires), des métalloprotéinases matricielles mutées; au moins un reste d'acide aminé à une position définie dans la protéine ayant été transformé en un reste d'aminoacide hydrophile et/ou chargé, de manière à obtenir une meilleure stabilité face à l'autoprotéolyse.
Banci Lucia
Bertini Ivano
Del Conte Rebecca
Fragai Marco
Luchinat Claudio
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Protera S.r.l.
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