Use of mcrp for delivery of materials into cells

Details Use of mcrp for delivery of materials into cells Use of mcrp for delivery of materials into cells

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A61K 38/00 (2006.01) A61K 47/48 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C12N 15/87 (2006.01)

Patent

CA 2341309

The invention provides a method of delivering a material into a cell. The method comprises associating the material with a modified C-reactive protein (mCRP) or a mutant-mCRP. Then, the material associated with the mCRP or the mutant-mCRP is contacted with the cell so that the material is delivered into the cell. The invention also provides a kit comprising one or more containers. In one embodiment, one of the containers holds a material to be delivered into a cell in association with a modified C-reactive protein (mCRP) or a mutant- mCRP. Alternatively, one of the containers holds the material to be delivered into the cell, and a second container holds the mCRP or the mutant-mCRP.

L'invention concerne un procédé d'apport d'une substance dans une cellule. Ce procédé consiste à associer la substance à une protéine modifiée C-réactive (mCRP) ou à une mCRP mutante puis à mettre la substance associée à la mCRP ou à la mCRP mutante en contact avec la cellule, de manière à assurer l'apport de la substance dans cette dernière. L'invention concerne également un kit comprenant un ou plusieurs récipients. Dans un mode de réalisation, un des récipients contient une substance apportée dans une cellule en association avec une protéine modifiée C-réactive (mCRP) ou avec une mCRP mutante. En variante, un des récipients contient la substance à apporter dans la cellule alors que l'autre récipient contient la mCRP ou la mCRP mutante.

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