Use of mdck cells in the evaluation of cholesterol modulators

Details Use of mdck cells in the evaluation of cholesterol modulators Use of mdck cells in the evaluation of cholesterol modulators

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C12N 5/10 (2006.01) C12Q 1/02 (2006.01) C12Q 1/60 (2006.01) G01N 33/567 (2006.01)

Patent

CA 2691267

A novel use for MDCK cells in the evaluation of cholesterol modulators is provided. In particular, methods for detecting substances which bind to NPC1L1 and block intestinal cholesterol absorption are provided. Such substances are of use in the treatment of individuals with hypercholesterolemia. The various assays may additionally be employed for studying NPC1L1 function.

L'invention porte sur une nouvelle utilisation de cellules MDCK dans l'évaluation de modulateurs du cholestérol. En particulier, l'invention porte sur des procédés pour détecter des substances qui se lient à NPC1L1 et bloquent l'absorption du cholestérol intestinal. De telles substances sont aptes à être utilisées dans le traitement d'individus ayant une hypercholestérolémie. Les divers essais peuvent de plus être employés pour étudier la fonction de NPC1L1.

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