A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 49/08 (2006.01) A61K 49/10 (2006.01)
Patent
CA 2491933
The invention relates to the use of metal complexes containing perfluoroalkyl as contrast agents in MR imaging for representing intravascular thrombi. Said complexes have a critical micelle-formation concentration < 10-3 mol/l, a hydrodynamic micelle diameter (2 Rh) > 1 nm and a proton relaxivity in plasma (R1) > 10 l/mmol.s.
L'invention concerne l'utilisation, en tant qu'agents de contraste pour l'imagerie par résonance magnétique, de complexes métalliques contenant du perfluoroalkyle et présentant une concentration critique de formation de micelles inférieure à 10?-3¿ mole/l, un diamètre micellaire hydrodynamique (2 Rh) supérieur à 1 nm et une relaxivité des protons dans le plasma (R?1¿) supérieure à 10 l/mmole.s, et ce pour la représentation de thrombus intravasculaires.
Kawata Yoko
Misselwitz Bernd
Niedballa Ulrich
Platzek Johannes
Weinmann Hanns-Joachim
Marks & Clerk
Schering Aktiengesellschaft
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