Use of metal salts to stabilize taxane-based compositions

Details Use of metal salts to stabilize taxane-based compositions Use of metal salts to stabilize taxane-based compositions

A - Human Necessities

61

K

A61K 31/337 (2006.01) A61K 9/00 (2006.01) A61K 9/107 (2006.01) A61K 9/48 (2006.01) A61K 31/28 (2006.01) A61K 31/355 (2006.01) A61K 38/13 (2006.01) A61K 47/02 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2404374

Disclosed are compositions containing a taxane, a carrier and a metal salt of an acid. Also disclosed are methods of stabilizing taxane/carrier compositions and reducing degradation of taxanese.g., during storage. The methods entail including the metal salt in the taxane composition or pretreating the carrier with the metal salt, optionally in combination with other pretreatments.

L'invention concerne des compositions contenant un taxane, un excipient, et un sel métallique d'un acide. L'invention concerne également des procédés permettant de stabiliser des compositions de taxane/excipient, et de réduire la dégradation des taxanes, par exemple, pendant un stockage. Ces procédés impliquent l'incorporation du sel métallique dans la composition de taxane, ou le préchauffage de l'excipient avec ledit sel métallique, éventuellement associé à d'autres prétraitements.

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