C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/34 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01)
Patent
CA 2542928
The present invention relates to the use of metallic cations, in particular zinc, to improve functional activity of antibodies. More particularly, said invention is concerned with pharmaceutical compositions, comprising antibodies with metallic cations.
La présente invention concerne l'utilisation de cations métalliques, notamment du Zinc, pour cristalliser le fragment Fc d~un anticorps anti Rhésus D. Mutagnèse dirigée des histidines situées aux residus 310 et 435.
Bourel Dominique
Ducancel Frederic
Glacet Arnaud
Jorieux Sylvie
Stura Enrico
Laboratoire Francais Du Fractionnement Et Des Biotechnologies
Lfb Biotechnologies
Smart & Biggar
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