C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2685376
The invention relates to a method of detecting LINE-I (long interspersed nucleotide elenients-1) DNA either methylated or unmethylated at the promoter region in a tissue or body fluid sample from a subject. Also disclosed are methods of using LINE-I DNA as a biomarker for diagnosing, predicting, and monitoring cancer progression and treatment.
La présente invention concerne un procédé de détection d'ADN LINE-I (longs éléments nucléotidiques dispersés 1) methylés ou non methylés au niveau de la région promotrice dans un échantillon de tissu ou de liquide organique prélevé d'un sujet. L'invention concerne également des procédés d'utilisation d'ADN LINE-I comme biomarqueur pour le diagnostic, la prédiction, et le suivi de la progression et du traitement du cancer.
Hoon Dave S.b.
Sunami Eiji
Hoon Dave S.b.
John Wayne Cancer Institute
Oyen Wiggs Green & Mutala Llp
Sunami Eiji
LandOfFree
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