Use of methylation status of mint loci and tumor-related...

Details Use of methylation status of mint loci and tumor-related... Use of methylation status of mint loci and tumor-related...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2710520

The invention relates to a method of detecting melanoma or breast cancer using DNA methylation in MINT 17, MINT31, or the promoter region of WIF1, TFP12, RASSF1A, SOCS1, GATA4, or RAR.beta.2 as a biomarker. Also disclosed are methods of using the biomarker for determining the cancer status and predicting the outcome of the cancer.

L'invention concerne une méthode de détection de mélanome ou de cancer du sein à l'aide d'une méthylation d'ADN dans MINT17, MINT31, ou de la région promotrice de WIF1, TFPI2, RASSF1A, SOCS1, GATA4, ou RARß2 en tant que biomarqueur. L'invention concerne également des méthodes d'utilisation du biomarqueur pour déterminer l'état cancéreux et prévoir l'évolution du cancer.

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