Use of mia in immunotherapy

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61K 38/11 (2006.01)

Patent

CA 2399028

The invention relates to the use of MIA to prevent inflammatory diseases and in particular their use in treatment of chronic destruction of articular cartilage. More specifically, MIA can be used to induce specific T-cell tolerance to the MIA antigen in patients suffering from rheumatoid arthritis.

L'invention concerne l'utilisation de la protéine MIA (inhibant le mélanome) pour la prévention de maladies inflammatoires et, en particulier, leur utilisation dans le traitement de la destruction chronique du cartilage articulaire. Plus spécifiquement, la MIA peut induire la tolérance spécifique des cellule T à l'antigène de MIA chez des patients souffrant de polyarthrite rhumatoïde.

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