Use of modified interleukin-8 proteins

Details Use of modified interleukin-8 proteins Use of modified interleukin-8 proteins

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61P 37/06 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2660260

The present invention relates to the use of a modified interleukin 8 (IL-8) having increased GAG binding affinity and further inhibited or down-regulated biological activity compared to the respective wild type IL-8 for preparing a medicament for the prevention and/or treatment of ischemia reperfusion injury and/or transplant rejection in patients.

La présente invention concerne l'utilisation d'une interleukine 8 (IL-8) modifiée présentant une affinité de liaison au GAG accrue et une activité biologique encore plus inhibée ou régulée négativement comparé à l'IL-8 de type sauvage respective pour la préparation d'un médicament destiné à la prévention et/ou au traitement d'une lésion d'ischémie-reperfusion et/ou d'un rejet de greffe chez des patients.

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