Use of moieties for binding to hyaluronan and icam-1

Details Use of moieties for binding to hyaluronan and icam-1 Use of moieties for binding to hyaluronan and icam-1

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 31/13 (2006.01) A61K 47/48 (2006.01) C07K 1/22 (2006.01) C08B 37/08 (2006.01) G01N 30/48 (1995.01)

Patent

CA 2195386

The use of an effective amount of a compound having the general formula RR1N(CH2)mNR2R3 or containing the moiety of the formula (see fig. I) for the inhibition of the ICAM-1, wherein R and R1 are selected from H and (see fig. II) and R2 and R3 are selected from H, (see fig. III), (see fig. IV) and (see fig. V) and wherein m is an integer from 1-12.

Utilisation d'une quantité efficace d'un composé de formule générale RR1N(CH2)mNR2R3 ou contenant un groupement de formule (voir figure I) pour l'inhibition de la molécule d'adhérence intercellulaire ICAM-1, dans lesquelles R et R1 représentent un atome d'hydrogène ou (voir figure II), R2 er R3 représentent un atome d'hydrogène, (voir figure III), (voir figure IV) ou (voir figure V), et m est un nombre entier compris entre 1 et 12 inclusivement.

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