Use of molecular chaperones for the enhanced production of...

C - Chemistry – Metallurgy – 07 – K

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Details

C07K 14/755 (2006.01) C07K 14/81 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2529369

The present invention relates to a method for increased production of a secreted, recombinant protein product through the introduction of molecular chaperones in a ammalian host cell. The present invention also relates to a mammalian host cell with enhanced expression of a secreted recombinant protein product by coexpressing at least one chaperone protein.

La présente invention concerne un procédé pour augmenter la production d'un produit protéique recombinant via l'introduction de chaperons moléculaires dans une cellule hôte mammalienne. La présente invention concerne aussi une cellule hôte mammalienne avec une expression améliorée d'un produit protéique recombinant sécrété par la coexpression d'au moins une protéine chaperonne.

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