A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/30 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01)
Patent
CA 2703466
The invention relates to the use of monoclonal antibodies that only recognise the O-acetylated form of the GD2 ganglioside, or fragments of said antibody, for the diagnosis and the treatment of cancers in which the cells express the O-acetylated GD2, said antibody or said fragment recognising the O-acetylated GD2 molecules expressed by the tumoral cells and not recognising the GD2 molecules expressed at the surface of the peripheral nerves, in order to increase the specificity of the diagnosis and reduce the toxicity of the treatments. The invention also relates to artificially modified antibodies advantageously used for treating and diagnosing cancers in which the cells express the O-acetylated GD2.
L'invention concerne l'utilisation des anticorps monoclonaux ne reconnaissant que la forme O-acétylée du ganglioside GD2, ou fragment de cet anticorps pour le diagnostic et la thérapeutique de cancers dont les cellules expriment le GD2 O-acétylé, ledit anticorps ou ledit fragment reconnaissant les molécules de GD2 O-acétylé exprimées par les cellules tumorales et ne reconnaissant pas les molécules de GD2 exprimées à la surface des nerfs périphériques pur augmenter la spécificité du diagnostic et diminuer la toxicité des traitements. L'invention concerne également les anticorps modifiés articifiellement utilisés avantageusement pour le traitement et le diagnostic de cancers dont les cellules expriment le GD2 O- acétylé.
Aubry Jacques
Barbet Jacques
Birkle Stephane
Chatal Jean-Francois
Mussini Jean-Marie
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universite de Nantes
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