C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0786 (2010.01) A61K 35/14 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2321181
The invention relates to monocyte derived cells, in a purified form and substantially free of contaminants, presenting antigenic epitopes on their membranes after interiorization and processing of at least an antigen-antibody complex formed between an antigen and an antibody, under appropriate conditions, said epitopes corresponding to proteolytic degradation products of said antigen, with said antibody being directed against a tumor or against an infectious agent, and with said antigen being fragments of tumor or of infectious agent, including membranes or tumor apoptotic bodies, or purified tumor or infectious antigens or being recombinant tumor or infectious antigens.
L'invention concerne des cellules dérivées de monocytes, sous une forme purifiée et sensiblement exempte de contaminants, dont les membranes présentent des déterminants antigéniques après intériorisation et traitement d'au moins un complexe antigène-anticorps créé entre un antigène et un anticorps, dans des conditions appropriées, lesdits déterminants antigéniques correspondant à des produits de dégradation protéolytique dudit antigène, ledit anticorps étant dirigé contre une tumeur ou contre un agent infectieux et ledit antigène étant constitué par des fragments d'agent tumoral ou infectieux, y compris des membranes ou des corps d'apoptose tumorale, ou par des antigènes tumoraux ou infectieux purifiés ou des antigènes tumoraux ou infectieux de recombinaison.
Bartholeyns Jacques
Fouron Yves
Romet-Lemonne Jean-Loup
Fetherstonhaugh & Co.
I.d.m. Immuno-Designed Molecules
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