Use of mtor inhibitors to enhance t cell immune responses

Details Use of mtor inhibitors to enhance t cell immune responses Use of mtor inhibitors to enhance t cell immune responses

A - Human Necessities

61

K

A61K 31/4745 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2733203

It is disclosed herein that treatment of a subject with an mTOR inhibitor enhances antigen-specific T cell immune responses. Thus, provided herein is a method of enhancing an antigen-specific T cell response in a subject by administering to the subject a therapeutically effective amount of an mTOR inhibitor. The antigen can be any antigen, such as an antigen from a pathogen or a vaccine, or a tumor antigen. In some embodiments, the method further comprises administering to the subject a vaccine, such as a virus vaccine or a cancer vaccine. The mTOR inhibitor can be administered either before or after vaccination to enhance the quantity and quality of the T cell immune response and immunological memory. In some examples, the mTOR inhibitor is rapamycin or a rapamycin analog.

Selon la présente invention, le traitement dun sujet avec un inhibiteur de mTOR augmente les réponses immunitaires de lymphocytes T antigène-spécifiques. Par conséquent, la présente invention concerne un procédé daugmentation dune réponse de lymphocytes T antigène-spécifique chez un sujet par administration au sujet dune quantité thérapeutiquement efficace dun inhibiteur de mTOR. Lantigène peut être un antigène quelconque, tel quun antigène dun pathogène ou dun vaccin, ou un antigène tumoral. Dans certains modes de réalisation, le procédé comprend en outre ladministration au sujet dun vaccin, tel quun vaccin antiviral ou un vaccin anticancéreux. Linhibiteur de mTOR peut être administré avant ou après vaccination pour augmenter la quantité et la qualité de la réponse immunitaire de lymphocytes T et la mémoire immunologique. Dans certains exemples, linhibiteur de mTOR est la rapamycine ou un analogue de la rapamycine.

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