Use of mutant herpes simplex virus-2 for cancer therapy

Details Use of mutant herpes simplex virus-2 for cancer therapy Use of mutant herpes simplex virus-2 for cancer therapy

A - Human Necessities

61

K

A61K 48/00 (2006.01)

Patent

CA 2613310

The present invention is directed to the composition and use of a modified Herpes Simplex Virus Type 2 (HSV-2) as a medicament in the treatment of cancer. The modified HSV-2 has fusogenic activity, and comprises a modified/mutated ICP10 polynucleotide encoding a polypeptide having ribonucleotide reductase activity and lacking protein kinase activity.

L'invention concerne la composition et l'utilisation d'un herpès simplex virus type 2 modifié (HSV-2) en tant que médicament dans le traitement du cancer. Le HSV-2 modifié possède une activité fusogène, et comprend un polynucléotide ICP10 modifié/muté codant un polypeptide possédant l'activité de la ribonucléotide réductase et dépourvu de l'activité de la protéine kinase.

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