A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/551 (2006.01) A61P 25/14 (2006.01)
Patent
CA 2599922
Disclosed herein is the use of N-desmethylclozapine (NDMC) and related compounds to treat a variety of neuropsychiatric diseases including psychosis. It is shown that NDMC and related compounds are agonists or partial agonists at D2 and D3 dopamine receptors and thus may be effective as a dopamine stabilizing agent, allowing it to be used to treat or provide reduced incidence of Extrapyramidal symptoms (EPS) and/or tardive dyskinesias (TD). Also disclosed is administering NDMC and related compounds in combination with other anti-psychotic agents.
La présente invention se rapporte à l'utilisation de N-desméthylclozapine (NDMC) et de composés associés pour traiter une multitudes de maladies neuropsychiatriques, y compris la psychose. Cette invention montre que la NDMC et des composés associés constituent des agonistes ou des agonistes partiels des récepteurs de dopamine D2 et D3 et qu'il peuvent ainsi être efficaces comme agent stabilisateur de dopamine, ce qui leur permet d'être utilisés pour le traitement ou pour réduire l'incidence de symptômes extrapyramidaux (EPS) et/ou de dyskinésies tardives (TD). Selon cette invention, la NDMC et des composés associés sont administrés conjointement à d'autres agents antipsychotiques.
Acadia Pharmaceuticals Inc.
Smart & Biggar
LandOfFree
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