A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61K 9/127 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)
Patent
CA 2407132
A method is provided for inhibiting cellular uptake of cystine with a N- heterocyclic substituted salicylate for treatment such as sulfasalazine: Also provided we uses of a N-heterocyclic substituted Salicylate of cancer, for inhibition of cellular uptake of cystine, and for preparation of medicaments for the treatment of cancer or for inhibiting the cellular uptake of cystine. Preferably, the cancer is one which is dependent upon extracellular cystine or cysteine. Also provided are liposomal formulations of N-heterocyclic substituted salicylates.
La présente invention concerne un procédé permettant d'inhiber l'assimilation cellulaire de cystine, au moyen d'un salicylate N-hétérocyclique substitué, tel que la sulfasalazine. La présente invention concerne également l'utilisation d'un salicylate N-hétérocyclique substitué, en vue de traiter un cancer, d'inhiber l'assimilation cellulaire de cystine et de préparer des médicaments destinés au traitement du cancer ou à l'inhibition de l'assimilation cellulaire de cystine. Ledit cancer est de préférence un cancer dépendant de la cystine ou de la cystéine extracellulaire. En outre, cette invention concerne des formulations liposomales de salicylates N-hétérocycliques substitués.
Bruchovsky Nicholas
Gout Peter Wilhelm
Smart & Biggar
The University Of British Columbia
LandOfFree
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