Use of n-l-alpha-aspartyl-l-phenylalanine 1-methyl ester and...

Details Use of n-l-alpha-aspartyl-l-phenylalanine 1-methyl ester and... Use of n-l-alpha-aspartyl-l-phenylalanine 1-methyl ester and...

A - Human Necessities

61

K

A61K 38/05 (2006.01)

Patent

CA 2266098

N-L-.alpha.-Aspartyl-L-phenylalanine 1-methyl ester (APM) and its derivatives have been found to effect disease regression in osteoarthritis, osteoporosis, and rheumatoid arthritis. APM performs as a TNF-.alpha. antagonist as well as an antipyretic agent.

L'invention concerne la découverte que le N-L-.alpha.-Aspartyl-L-phénylalanine 1-méthyl ester (APM) et ses dérivés provoquent la régression de maladies telles que l'arthrose, l'ostéoporose et la polyarthrite. L'APM agit en tant qu'antagoniste de TNF-.alpha. ainsi que comme agent antipyrétique.

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