C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/26 (2006.01) A61P 9/10 (2006.01) C12Q 1/00 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2309881
A method for the prevention and treatment of atherosclerosis and its related diseases in mammals, in which an NADPH oxidase inhibitor is administered, is provided. The NADPH oxidase inhibitor prevents the production of reactive oxygen species upon exposure of endothetial cells to atherogenic LDL levels, thus resulting in decreased endocytosis and vascular hyperpermeability. Preferred NADPH oxidase inhibitors are of formula (I). Additionally, there is provided a diagnostic method for predicting risk of a human patient to atherosclerosis-related diseases.
Holland James A.
Johnson David K.
Gowling Lafleur Henderson Llp
The Research Foundation Of State University Of New York
LandOfFree
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