Use of native peptides and their optimized derivatives for...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/00 (2006.01) A61K 38/08 (2006.01) A61K 39/12 (2006.01)

Patent

CA 2606871

The present invention pertains to the field of vaccination, and more particularly to the fields of antitumor and antiviral vaccination. The invention relates to the use of a native peptide in a medicinal composition, for selecting and/or boosting part of a CTL immune response which has been initiated by an optimized immunogenic peptide derived from said native peptide. The invention also concerns vaccination kits which comprise several doses of optimized peptides and of their cognate native peptides.

L'invention concerne la vaccination, et plus particulièrement, la vaccination antivirale et antitumorale. L'invention concerne également l'utilisation d'un peptide natif dans une composition médicinale, pour sélectionner et/ou stimuler une partie de la réponse immunitaire des lymphocytes T cytotoxiques (CTL), déclenchée par un peptide immunogène optimisé dérivé dudit peptide natif. Par ailleurs, l'invention concerne des kits de vaccination qui contiennent plusieurs doses de peptides optimisés et de peptides natifs parents associés.

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