Use of neglected target tissue antigens in modulation of...

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A61K 38/02 (2006.01) A61K 38/17 (2006.01) A61K 38/28 (2006.01) A61K 39/00 (2006.01) C07K 1/00 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01) A61K 38/11 (2006.01)

Patent

CA 2328108

Disclosed are methods for identifying antigens, termed neglected target tissue antigens, that do not become involved as targets of an abnormal immune response (such as allergy or autoimmunity or more generally inflammation); also disclosed are methods of using NTTA for inducing regulatory responses and thereby abating abnormal inflammatory immune responses.

L'invention se rapporte à des procédés permettant d'identifier des antigènes, appelés antigènes tissulaires cibles négligés (NTTA), qui ne deviennent pas des cibles d'une réaction immunitaire anormale (telle qu'une allergie, une auto-immunité ou plus généralement une inflammation). L'invention se rapporte également à des procédés d'utilisation de ces antigènes NTTA pour induire des réactions de régulation et supprimer ainsi les réactions immunitaires inflammatoires anormales.

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