A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/18 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2619721
Nerve growth factor (NGF)1 in the form of a preparation for administration on the ocular surface, is proposed for use in the therapy and/or prophylaxis of pathologies affecting brain tissues and encephalic structures, with particular reference to pathologies affecting the hippocampus, cerebral cortex, basal forebrain, medial septum, Broca's diagonal band, Meynert's basal nucleus, substantia nigra pars compacta, striatum and cerebellum. Applied in the form of an external ophthalmic preparation, for example, as eye-drops or ointment, the NGF is able to pass from the ocular surface to the brain tissues, and has been found to exert a therapeutic action on pathologies of the central nervous system, and particularly on Alzheimer's Disease and Parkinson's Disease.
La présente invention concerne l'utilisation du facteur de croissance du nerf (NGF) sous la forme d'une préparation destinée à être administrée sur la surface oculaire dans le traitement et/ou la prophylaxie de pathologies affectant des tissus cérébraux et des structures encéphaliques, en particulier de pathologies affectant l'hippocampe, le cortex cérébral, le cerveau antérieur basal, le septum médian, la bande diagonale de Broca, le noyau basal de Meynert, la substantia nigra pars compacta, le striatum et le cervelet. Appliqué sous la forme d'une préparation ophtalmique externe, par exemple, comme gouttes ophtalmiques ou onguent, le facteur de croissance du nerf (NGF) est capable de passer de la surface oculaire aux tissus cérébraux et s'est avéré exercer une action thérapeutique sur des pathologies du système nerveux central, en particulier sur la maladie d'Alzheimer et la maladie de Parkinson.
Bonini Stefano
Lambiase Alessandro
Anabasis Srl
Dennison Associates
LandOfFree
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