A - Human Necessities – 61 – L
Patent
A - Human Necessities
61
L
A61L 33/00 (2006.01) A61K 31/00 (2006.01) A61K 31/04 (2006.01) A61K 31/095 (2006.01) A61K 31/195 (2006.01) A61K 31/21 (2006.01) A61K 31/275 (2006.01) A61K 31/295 (2006.01) A61K 31/41 (2006.01) A61K 31/535 (2006.01) A61K 33/00 (2006.01) A61K 38/17 (2006.01) A61K 38/38 (2006.01) A61K 38/49 (2006.01) A61K 38/55 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) A61K 47/48 (2006.01)
Patent
CA 2170772
This invention relates to the use of nitric oxide adducts to prevent platelet deposition and thrombus formation, on artificial surfaces which come into contact with blood. Suitable nitric oxide adducts include nitroglycerin, sodium nitroprusside, S-nitroso-proteins, S-nitrosothiols, long carbon-chain lipophilic S-nitrosothiols, S-nitroso- dithiols, iron-nitrosyl compounds, thionitrates, thionitrites, sydnonimines, furoxans, organic nitrates, and nitrosated amino acids. In addition, nitric oxide adducts may also be administered to an animal or human to coat a damaged vascular surface, thereby preventing thrombus formation or platelet deposition on the surface.
Cette invention se rapporte à des produits d'addition de l'oxyde nitrique utilisés pour prévenir le dépôt de plaquettes et la formation de thrombus sur des surfaces artificielles qui viennent en contact avec le sang. Les produits d'addition appropriés de l'oxyde nitrique comprennent la nitroglycérine, le nitroprussiate de sodium, les S-nitroso-protéines, les S-nitrosothiols, les S-nitrosothiols lipophiles à chaîne de carbone longue, les S-nitroso-dithiols, les composés de fer-nitrosyle, les thionitrates, les thionitrites, les sydnonimines, les furoxannes, les nitrates organiques et les acides aminés nitrosés. Les produits d'addition de l'oxyde nitrique peuvent être également administrés à un animal ou à un être humain afin de recouvrir une surface vasculaire endommagée, ce qui empêche la formation de thrombus ou le dépôt de plaquettes sur la surface.
Folts John D.
Loscalzo Joseph
Stamler Jonathan
Brigham And Women's Hospital
Folts John D.
Nitromed Inc.
Smart & Biggar
LandOfFree
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